Association of the A561C E-selectin polymorphism with systemic lupus erythematosus in 2 independent populations

El-Magadmi M., Alansari A., Teh L., Ordi J., Gul A., Inanc M., ...Daha Fazla

JOURNAL OF RHEUMATOLOGY, cilt.28, sa.12, ss.2650-2652, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 12
  • Basım Tarihi: 2001
  • Dergi Adı: JOURNAL OF RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2650-2652
  • Anahtar Kelimeler: systemic lupus erythematosus, genetics, association studies, E-selectin, ethnicity, TUMOR-NECROSIS-FACTOR, ATHEROSCLEROSIS, BINDING, DETECTS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective. E-selectin is expressed on cytokine stimulated endothelial cells and plays an important role in leukocyte-endothelium interactions and inflammatory cell recruitment. The gene for E-selectin is located at chromosome 1q23-25 within the linkage area for systemic lupus erythematosus (SLE). The best characterized polymorphism in E-selectin molecule is A561C. which codes for Ser128Arg. We studied the prevalence of the A561C E-selectin gene polymorphism in patients with SLE and controls from 3 different ethnic populations.