Fused heterocycles: Synthesis of some new imidazo[1,2-a]-pyridine derivatives

Kasimogullari B. Ö., Cesur Z.

MOLECULES, cilt.9, sa.10, ss.894-901, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 10
  • Basım Tarihi: 2004
  • Doi Numarası: 10.3390/91000894
  • Dergi Adı: MOLECULES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.894-901
  • İstanbul Üniversitesi Adresli: Evet

Özet

Some new thiazolidines and spirothiazolidines derived from hydrazones of 2-methylimidazo[1,2-a]pyridine-3-carboxylic acid hydrazide, a bioisosteric derivative of isoniazid, were synthesized and characterized by analytical, IR, H-1- and C-13-NMR and mass spectral data. Some of the newly synthesized compounds were screened for their antimycobacterial activities. None of the tested compounds showed significant in vitro antituberculous activity at 6.25 mu g/mL (MIC rifampin 0.031 mu g/mL).