Akademik Veri Yönetim Sistemi
Sabiad , cilt.7, sa.1, ss.61-67, 2024 (Hakemli Dergi)
ABSTRACT
Objectives: Meloxicam (MEL) is a selective cyclooxygenase inhibitor of
enolic acid class drugs with analgesic and antipyretic effects. In this study,
an easy, selective, fast, and sensitive third-order derivative
spectrophotometric method was developed and validated for the
determination of MEL in tablet formulation.
Material and Methods: The absorption of MEL in a solution of methanol
and 1 M sodium hydroxide (1:1, v/v) mixture was measured using the
peak-to-zero method. This solution was found to be the most suitable for
determining the drug by third-order derivative spectrometry. The
wavelength at which the maximum absorption was achieved in the
measurements was 341nm. The developed method has been validated in
accordance with the International Conference on Harmonization
guidelines (ICH).
Results: The linear working range was 1.0 - 14.0 µg/mL. The limit of
detection (LOD) and limit of quantification (LOQ) values were 0.22 and
0.75 μg/mL, respectively. The method was validated for linearity, accuracy,
precision, recovery, and stability. The developed method was performed
for the quantification of MEL in tablets, and the recovery percentage was
found to be between 97.50% and 98.12%.
Conclusion: The results show that the method is easy, simple, inexpensive,
and fast compared to other published methods, in addition to being
accurate and sensitive. The proposed method can be used as a very
convenient alternative for the determination of MEL in pharmaceutical
formulations in routine analysis in quality control.