Intrarenal application of N-acetylcysteine for the prevention of contrast medium-induced nephropathy in primary angioplasty

Aslanger E., Uslu B., Akdeniz C., Polat N., Cizgici Y., Oflaz H.

CORONARY ARTERY DISEASE, cilt.23, sa.4, ss.265-270, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1097/mca.0b013e328351aacc
  • Dergi Adı: CORONARY ARTERY DISEASE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.265-270
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective Contrast medium-induced nephropathy (CIN) is a well-known complication of coronary angiographic procedures, especially in patients treated with primary angioplasty. To prevent CIN, we examined using a local application of N-acetylcysteine (NAC) for the prevention of CIN during primary angioplasty. We hypothesized that a local application of NAC into the renal arteries would provide the benefit of a higher local concentration, lower first-pass metabolism, and faster efficacy. To evaluate the effects of NAC by the intrarenal route, we performed a prospective, randomized clinical study in patients with acute myocardial infarction treated with primary angioplasty.