Cyclosporine-associated hyperkalemia: Report of four allogeneic blood stem-cell transplant cases

Caliskan Y., Kalayoglu-Besisik S., Sargin D., Ecder T.

Transplantation, cilt.75, sa.7, ss.1069-1072, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 75 Sayı: 7
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1097/01.tp.0000057241.69355.59
  • Dergi Adı: Transplantation
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1069-1072
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background. Nephrotoxicity is a well-known effect of cyclosporine (CsA) that causes a reduction in glomerular filtration rate through vasoconstriction of the afferent glomerular arterioles and may result in acute renal failure. Isolated CsA-induced hyperkalemia occurring through different mechanisms is also common. However, there are only a few "case reports" addressing this phenomenon in allogeneic bone marrow transplantation patients. In this report, we propose mechanisms and methods of managing CsA-associated hyperkalemia in allogeneic transplantation.