Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women

Guclu-Geyik F., Erkan A. F., Ozuynuk A. S., Ekici B., Coban N.

TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY, cilt.50, sa.1, ss.34-46, 2022 (ESCI) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.5543/tkda.2022.21003
  • Dergi Adı: TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.34-46
  • Anahtar Kelimeler: Intelectin-1, ITLN1 gene, coronary artery disease, Val109Asp, SERUM OMENTIN-1 LEVELS, ADIPOSE-TISSUE, RISK, ADIPOKINES, ATHEROSCLEROSIS, RECEPTOR, LIPIDS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Intelectin-1 is an anti-inflammatory adipokine encoded by the Intelectin 1 (ITLN1) gene. Genetic variations in the ITLN1 gene affect the risk of coronary artery disease (CAD) and related CAD risk factors. In this study, we aimed to investigate whether the ITLN1 gene Val109Asp polymorphism has an effect on the severity of CAD and serum lipid levels in both men and women.