Aberrant Activation-Inducec Cyticine Deaminase Gene Expression Links BCR/ABL1-Negative Classical Myeloproliferative Neoplasms

Dermenci H., Aday A., Teker A. B. A., Hancer V. S., Gelmez M. Y., Nalcaci M., ...Daha Fazla

HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI, cilt.60, sa.3, ss.228-233, 2022 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.4274/haseki.galenos.2022.8133
  • Dergi Adı: HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.228-233
  • Anahtar Kelimeler: Cytidine deaminase, mutations, genomic instability, IMMUNOGLOBULIN EXPRESSION, AID, MUTATION, JAK2
  • İstanbul Üniversitesi Adresli: Evet

Özet

Aim: Activation-induced cytidine deaminase (AID) has been associated with tumor initiation and development because of its ability to generate DNA damage and somatic mutations that cause genomic instability. This study aimed to investigate the relationship between AID expression levels and the risk of developing BCR/ABL1-negative myeloproliferative neoplasms (MPNs) by comparing the AID expression levels of the patients and controls.