Biochemical evaluation of oxidative stress in propylthiouracil treated hyperthyroid patients. Effects of vitamin c supplementation

Seven A. N., Tasan E., Inci F., Hatemi H., Burcak G.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, cilt.36, sa.10, ss.767-770, 1998 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 10
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1515/cclm.1998.136
  • Dergi Adı: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.767-770
  • İstanbul Üniversitesi Adresli: Evet

Özet

In this study the impact of vitamin C supplementation on oxidative damage as assessed by thiobarbituric acid reactive substances and markers of antioxidant status: namely Cu/Zn superoxide dismutase, glutathione peroxidase, glutathione reductase and glutathione were investigated in 24 hyper-thyroid patients under propylthiouracil therapy (3x100 mg/day) for five days and in 15 healthy controls. Ascorbic acid (1000 mg/day) was given as a supplement for 1 month to both the patients and controls during the study period. Heparinised blood samples were taken at the beginning and the end of one month ascorbic acid supplementation.