Development and Evaluation of Combined Effect Buccal Films for Treatment of Oral Candidiasis

Arslan D., AKBAL DAĞISTAN Ö., SAĞIRLI A. O., DURMUŞOĞLU L., CEVHER E., YILDIZ PEKÖZ A.

AAPS PHARMSCITECH, cilt.24, sa.1, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 1
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1208/s12249-022-02477-5
  • Dergi Adı: AAPS PHARMSCITECH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, EMBASE, International Pharmaceutical Abstracts, MEDLINE
  • Anahtar Kelimeler: buccal drug delivery, hydrocortisone acetate, lidocaine hydrochloride, mucoadhesive film, nystatin, oral candidiasis, xanthan gum
  • İstanbul Üniversitesi Adresli: Evet

Özet

Buccal film formulations, including antifungal nystatin, anti-inflammatory agent hydrocortisone acetate, and local anesthetic lidocaine hydrochloride for pain relief, were developed. Bioadhesive films were fabricated with hydrophilic polymers, hydroxyethyl cellulose (HEC), and xanthan gum (XG) and dried in the incubator. Textural, swelling, and bioadhesive prop-erties, physicochemical and in vitro release characteristics, and antifungal activities of bioadhesive films were evaluated. Bioadhesive films significantly extended nystatin release by prolonging retention time of the target area formulation while rapidly releasing hydrocortisone acetate and lidocaine HCl, reducing drug administration. The polymer type affected bioadhe-sion strength and erosion ratio, and XG formulations had more polymer suitability. Consequently, XT-O2 formulation that was prepared with xanthan gum and tween 80, was best for its highest antifungal film activity (20.00 +/- 0.07 mm), released nystatin (44.296% +/- 1.695), and lowest erosion matrix (36.719% +/- 0.249). The selected formulation can be used for compatibility, stabil-ity and in vivo studies targeted oral candidiasis infections.