Extracellular genetic materials and their application in clinical practice.

Koçana C. Ç., Toprak S. F., Sözer S.

Cancer genetics, cilt.252, ss.48-63, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 252
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.cancergen.2020.12.006
  • Dergi Adı: Cancer genetics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.48-63
  • Anahtar Kelimeler: EGM, Cell-free DNA, Oncogenesis, Genometastasis, CELL-FREE DNA, CIRCULATING NUCLEIC-ACIDS, CANCER-PATIENTS, TUMOR DNA, ACQUIRED-RESISTANCE, BLOOD-PLASMA, IN-VITRO, EXOSOMES, MUTATIONS, MICRORNAS
  • İstanbul Üniversitesi Adresli: Evet

Özet

This study reviews the possible origins, functional roles, and diagnostic applications of 'extracellular genetic material' (EGM), a novel term introduced to cover DNA, RNA, and DNA/RNA-related molecules released from all types of cells into the extracellular region. The literature on EGMs shows them to play a dual role in diverse, fine-tuning mechanisms involved in both homeostasis and pathological events, including cancerogenesis and genometastasis. Recent developments in the next-generation technology have provided successful applications of low quantities of genomic materials into the diagnostic field, yielding high sensitivity and specificity in test results. Also, the successful application of EGMs into diagnostics has afforded promising outcomes for researchers and clinicians. This study of EGM provides a deeper understanding of the subject as an area of interest, especially cell-free DNA, aiming toward the eventual development of new therapeutic applications and diagnostic strategies. (C) 2020 Elsevier Inc. All rights reserved.