The risk of hepatotoxicity during long-term and low-dose flutamide treatment in hirsutism

DİKENSOY E., Balat O., PENÇE S., AKÇALI C., ÇİÇEK H.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, cilt.279, sa.3, ss.321-327, 2009 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 279 Sayı: 3
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s00404-008-0719-z
  • Dergi Adı: ARCHIVES OF GYNECOLOGY AND OBSTETRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.321-327
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Flutamide is an effective drug in treatment of hirsutism. Hepatotoxicity occasionally may occur with therapeutic doses (750-1500 mg/day), 3 months after initiation of treatment. Monitoring of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels is recommended to obviate serious hepatotoxicity.