Effects of insulin-like growth factor-I and platelet-rich plasma on sciatic nerve crush injury in a rat model

Emel E., Ergun S. S., KOTAN D., Gursoy E. B., Parman Y., Zengin A., ...Daha Fazla

JOURNAL OF NEUROSURGERY, cilt.114, sa.2, ss.522-528, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 114 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3171/2010.9.jns091928
  • Dergi Adı: JOURNAL OF NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.522-528
  • Anahtar Kelimeler: crush injury, insulin-like growth factor-I, platelet-rich plasma, rat, PERIPHERAL-NERVE, IGF-I, NEURITE OUTGROWTH, FACTOR PDGF, REGENERATION, EXPRESSION, REPAIR, MANAGEMENT, MITOGENS, SYSTEM
  • İstanbul Üniversitesi Adresli: Evet

Özet

Object. Local administration of insulin-like growth factor-I (IGF-I) has been shown to increase the rate of axon regeneration in crush-injured and freeze-injured rat sciatic nerves. Local administration of platelet-rich plasma (PRP) has been also shown to have a measurable effect on facial nerve regeneration after transection in a rat model. The objective of the study was to compare the effects of locally administered IGF-I and PRP on the parameters of the Sciatic Function Index (SFI), sensory function (SF), axon count, and myelin thickness/axon diameter ratio (G-ratio) in a rat model of crush-injured sciatic nerves.