Transcranial direct current stimulation does not improve clinical and neurophysiological outcomes in panic disorder: A randomized sham-controlled trial

AKSU S., Soyata A. Z., Mursalova Z., Eskicioglu G., Tukel R.

PSYCHIATRY AND CLINICAL NEUROSCIENCES, cilt.76, sa.8, ss.384-392, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 76 Sayı: 8
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1111/pcn.13378
  • Dergi Adı: PSYCHIATRY AND CLINICAL NEUROSCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE, Psycinfo
  • Sayfa Sayıları: ss.384-392
  • Anahtar Kelimeler: anxiety disorders, neurophysiology, non-invasive brain stimulation, panic disorder, transcranial direct current stimulation, DORSOLATERAL PREFRONTAL CORTEX, COGNITIVE-BEHAVIOR THERAPY, ATTENTIONAL BIAS, FACIAL EXPRESSIONS, BODY VIGILANCE, NEUROCOGNITIVE MECHANISMS, MAGNETIC STIMULATION, EMOTIONAL ATTENTION, ANXIETY DISORDER, PLACEBO-RESPONSE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Aim Emerging evidence suggests that transcranial direct current stimulation (tDCS) has anxiolytic effects and may enhance emotional processing of threat and reduce threat-related attentional bias. Panic disorder (PD) is considered to be a fear network disorder along with prefrontal activity alterations. We aim to assess the effect of tDCS on clinical and physiological parameters in PD for the first time. Methods In this triple-blind randomized sham-controlled pilot study, 30 individuals with PD were allocated into active and sham groups to receive 10 sessions of tDCS targeting the dorsolateral prefrontal cortex bilaterally at 2 mA for 20-min duration over 2 weeks. The clinical severity, threat-related attentional bias, interoceptive accuracy, and emotional recognition were assessed before, immediately after, and 1 month after tDCS. Results Active tDCS, in comparison to sham, did not elicit more favorable clinical and neuropsychological/physiological outcomes in PD. Conclusion The present study provides the first clinical and neurobehavioral results of prefrontal tDCS in PD and indicates that prefrontal tDCS was not superior to sham in PD.