Optimization of piribedil mucoadhesive tablets for efficient therapy of Parkinson's disease: physical characterization and ex vivo drug permeation through buccal mucosa

Celik B., Ozdemir S., Demirkoz A. B., Uner M.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, cilt.43, sa.11, ss.1836-1845, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 11
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/03639045.2017.1349785
  • Dergi Adı: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1836-1845
  • Anahtar Kelimeler: Buccal tablets, controlled release, direct compression, hydroxypropyl methyl cellulose, mucoadhesion, piribedil, IN-VITRO, CONTROLLED-RELEASE, MATRIX TABLETS, DELIVERY, FORMULATION, MECHANISMS, POLYMERS, DESIGN, TRANSPORT
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: The aim of this study was optimization of buccal piribedil (PR) mucoadhesive tablets to improve its low bioavailability and provide controlled release for the treatment of Parkinson's disease.