Acute beneficial effect of fluosol-DA on urinary excretion of stroma-free hemoglobin in the isolated rat kidney

Millis R. M., Barber J. D., Anderson W. A., Dehkordi O., Toussaint R., Ertugrul L.

Renal Failure, cilt.16, sa.3, ss.325-335, 1994 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 3
  • Basım Tarihi: 1994
  • Doi Numarası: 10.3109/08860229409044873
  • Dergi Adı: Renal Failure
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.325-335
  • İstanbul Üniversitesi Adresli: Hayır

Özet

In a timed study over 75 min, divided into 5 15-min periods, experimental perfusions of isolated rat kidneys using Krebs-Ringer bicarbonate (KRB) containing 3.5% (uncrosslinked) stroma-free hemoglobin (SFH) plus 3.5% of the perfluorochemical Fluosol-DA were found to excrete only 13% as much total hemoglobin (Hb) as control perfusions using KRB contuinitzg 7% SFH alone (controls). The glomerular filtration rate was the same for experimen-tals and controls in 3 periods, and slightly higher in the experimentals in 2 periods. However, urine flow was found to be significantly decreased in all 5 periods for the experimentals relative to the controls. These effects can be explained by reabsorption of glomerular filtrate containing Hb by endocytosis of renal tubular cells. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.