Angiotensin-converting enzyme gene polymorphism in arrhythmogenic right ventricular dysplasia: is DD genotype helpful in predicting syncope risk?

Ozben B., Altun I., Hancer V. S., Bilge A. K., Tanrikulu A. M., Diz-Kucukkaya R., ...Daha Fazla

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, cilt.9, sa.4, ss.215-220, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 4
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1177/1470320308099126
  • Dergi Adı: JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.215-220
  • Anahtar Kelimeler: angiotensin-converting enzyme gene pollymorphism, arrhythmogenic right ventricular dysplasia, sudden cardiac death, syncope, ventricular tachycardia, INSERTION DELETION POLYMORPHISM, ESSENTIAL-HYPERTENSION, SUDDEN-DEATH, WOOLLY HAIR, CARDIOMYOPATHY, ASSOCIATION, ARRHYTHMIAS, MUTATIONS, DISEASE, DYSPLASIA/CARDIOMYOPATHY
  • İstanbul Üniversitesi Adresli: Evet

Özet

Introduction. Arrhythmogenic right ventricular dysplasia (ARVD) is a heritable disorder characterised by fibrofatty replacement of right ventricular myocytes and increased risk of ventricular arrhythmias and sudden cardiac death. Angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D)) polymorphism affects myocardial ACE levels. DD genotype favours myocardial fibrosis and is associated with malignant ventricular tachycardia. The aim of this study was to explore ACE gene polymorphism in ARVD patients.