Antibacterial diterpenes from the roots of Salvia viridis

Ulubelen A., Oksuz S., Kolak U., Bozok-Johansson C., Celik C., Voelter W.

PLANTA MEDICA, cilt.66, sa.5, ss.458-462, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 66 Sayı: 5
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1055/s-2000-8596
  • Dergi Adı: PLANTA MEDICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.458-462
  • Anahtar Kelimeler: Salvia viridis, Lamiaceae, diterpenoids, antibacterial activity, ABIETANE DITERPENES, PODOCARPUS, TERPENOIDS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Three new diterpenes, salviviridinol, viridinol, viridone, five known diterpenes, sugiol, 1-oxoferruginol, ferruginol, aethiopinone and microstegiol, abietane and rearranged abietane diterpenes were isolated from the roots of Salvia viridis. These compounds were assayed against S. aureus ATCC 6538 P, E. coli ATCC 8739, P. mirabilis ATCC 14153, K. pneumonia ATCC 4352, P. aeruginosa ATCC 27853, S. epidermidis ATCC 12228, E. faecalis ATCC 29212 and a yeast C. albicans ATCC 10231. 1-Oxoferruginol showed activity against B. subtilis, S. aureus, S. epidermidis and a modest activity against P. mirabilis, migrostegiol had a little activity against B. subtilis. The structures of the compounds were established by 1D and 2D NMR spectroscopic techniques.