Investigation of SR-BI gene rs4238001 and rs5888 polymorphisms prevalence and effects on Turkish patients with metabolic syndrome

Filizfidan M., Pence S., Caykara B., Alsaadoni H., MARAKOĞLU K., Pence H. H., ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.45, sa.4, ss.435-441, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1515/tjb-2018-0499
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.435-441
  • İstanbul Üniversitesi Adresli: Evet

Özet

Aim: Metabolic syndrome (MS) is associated with dyslipidemia such as hypertriglyceridemia and high-density lipoprotein (HDL) levels. Scavenger receptor BI (SR-BI) is the transmembrane receptor that regulates selective intake of cholesterol esters by the liver and it binds to HDL with high affinity. This study was aimed to determine the effects of SR-BI gen variations upon proatherogenic and antiatherogenic lipid profiles in the patients with metabolic syndrome.