Evaluating the effectiveness of anti-tuberculosis treatment by detecting Mycobacterium tuberculosis 85B messenger RNA expression in sputum

ATAHAN E., Saribas S., DEMİRCİ M., AKKUŞ S., Satana D., Ziver T., ...Daha Fazla

JOURNAL OF INFECTION AND PUBLIC HEALTH, cilt.13, sa.10, ss.1490-1494, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 10
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.jiph.2020.05.016
  • Dergi Adı: JOURNAL OF INFECTION AND PUBLIC HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.1490-1494
  • Anahtar Kelimeler: 85B mRNA, Mycobacterium tuberculosis, Anti-tuberculosis treatment, PCR, STABILITY, SURROGATE, MARKER, DNA
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: The antigen 85 complex (85B) is secreted in large quantities from growing mycobacteria and the presence of bacterial mRNA is an indicator of cell viability. The quantitative detection of 85B mRNA expression levels can be used to assess the success of anti-tuberculosis treatment outcomes to detect viable mycobacteria cells. Therefore, we evaluated the levels of 85B mRNA of Mycobacterium tuberculosis strains in patients with pulmonary tuberculosis.