Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva

Zhang H., Tamez P., Aydogmus Z., Tan G., Saikawa Y., Hashimoto K., ...Daha Fazla

PLANTA MEDICA, cilt.68, sa.12, ss.1088-1091, 2002 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 12
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1055/s-2002-36350
  • Dergi Adı: PLANTA MEDICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1088-1091
  • Anahtar Kelimeler: Ficus fistulosa, Moraceae, Rhaphidophora decursiva, Araceae, antimalarial activity, bioassay-directed fractionation, trictiothecene sesquiterpenoids, verrucarin L acetate, roridin E
  • İstanbul Üniversitesi Adresli: Evet

Özet

Bioassay-directed fractionation of an extract prepared from the dried leaves and stem barks of Ficus fistulosa Reinw. ex Blume (Moraceae) led to the isolation of verrucarin L acetate (1), together with 3alpha-hydroxyisohop-22(29)-en-24-oic acid, 3beta-gluco-sitosterol, 3,4-dihydro-6,7-dimethoxyisocarbostyril, 3,4,5-trimethoxybenzyl alcohol, alpha-methyl-3,4,5-trimethoxybenzyl alcohol, indole-3-carboxaldehyde, palmanine, and aurantiamide acetate. Roridin E (2) was identified in a subfraction from the dried leaves and stems of Rhaphidophora decursiva Schott (Araceae). Verrucarin L acetate and roridin E were characterized as macrocyclic trichothecene sesquiterpenoids and found to inhibit the growth of Plasmodium falciparum with IC50 values below I ng/ml.