Akademik Veri Yönetim Sistemi
Ege Tıp Bilimleri Dergisi, cilt.2, sa.1, ss.50-51, 2019 (Hakemli Dergi)
Effects of
Balneological Treatment on Biomarkers in Osteoarthritis
Dr. Tuba Adıgüzel1 , Prof. Dr. Hatice Gürdal1 1 Department
of Medical Ecology and Hydroclimatology, İstanbul Faculty of Medicine, İstanbul
University, Turkey tuba.adiguzel@istanbul.edu.tr
Background:
Balneological treatment (BT) is one of the most commonly used
non-pharmacological approach for osteoarthritis (OA). Recent studies indicate
that BT may effect serum/urine biomarkers that play role in the pathopyhsiology
of OA. Objective: To present the data on the serum/urine biomarkers in OA
patients that undergo mudbath therapy. Methods: Literature search by Medline to
identify randomised controlled studies on the serum biomarkers of
osteoarthritis patients that treated with balneotherapy with/or peloidotherapy.
Results: 12 studies were found between 1995-2018 that describe the effects of
balneological treatment on substances involved in anabolic-catabolic processes
of cartilage and the inflammatory reactions. Catabolic cytokines (IL-1, TNF-α)
are main mediators of joint damage in OA. Matrix metalloproteinases also
frequently implicated in the destruction of articular cartilage. Experimental
evidence is emerging that BT decrease the serum concentrations of these
cytokines and proteinases. Studies documents the increase of IGF-1 that has a
protective influence on cartilage structure after BT. Cartilage turn-over
markers like YKL-40 and CTX-II also improved after BT. Recently it has been
showed that BT is able to affect the synthesis of PGE2 and other pain related
mediators like LTB4. Also BT can exert beneficial effects on cartilage
homeostasis and inflammatory reactions by influencing NO and decreasing
myelopeoxidase serum values. Conclusion: It is suggested that balneological
treatment can control and decrease the inflammatory reactions, joint damage and
consequently, relief the pain in OA patients. Keywords: Balneotherapy, Mud,
Cytokine