EVALUATION OF PTEN AND PI3K/AKT EXPRESSIONS IN STANOZOLOL-TREATED RAT KIDNEYS

Kotil T., SEVİM Ç., Kara M.

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, 2022 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2022
  • Doi Numarası: 10.26650/iuitfd.2022.909985
  • Dergi Adı: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Anahtar Kelimeler: Stanozolol, Kidney, PTEN, PI3K, Akt1, ANDROGENIC STEROIDS, MEDIATED APOPTOSIS, SEVERE CHOLESTASIS, ANABOLIC-STEROIDS, PHYSICAL-ACTIVITY, OXIDATIVE STRESS, RENAL-FAILURE, NANDROLONE, PHOSPHORYLATION, SUPPLEMENTS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Stanozolol is an anabolic androgenic steroid (MS) that is widely used by teenagers and athletes in bodybuilding, sports, and athletics. The potential effects of stanozolol in kidney functions have not been defined. In this study we investigated the expression of tumor suppressor protein phosphatase and tensin homolog (Pten) and mRNA levels of phosphatidylinositol 4,5-bisphosphate 3 kinase (Pi3k) and the protein kinase B (Akt1) signaling pathway in rat kidneys treated by stanozolol.